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Báo cáo y học: "An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice. | Respiratory Research BioMed Central Research An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation but worsens airway function in house dust mite sensitive mice Rosa Torres1 4 Aida Herrerias2 Mariona Serra-Pagès2 Jordi Roca-Ferrer1 4 Laura Pujols1 4 Alberto Marco3 César Picado1 4 and Fernando de Mora 2 Address Department of Pneumology and Respiratory Allergy Hospital Clinic IDIBAPS Universitat de Barcelona Barcelona Spain 2Department of Pharmacology Universitat Autònoma de Barcelona Barcelona Spain 3Department of Animal Pathology Universitat Autònoma de Barcelona Barcelona Spain and 4CIBER Centro de Investigación Biomédica en Red de Enfermedades Respiratorias Spain Email Rosa Torres - rosa.torres@uab.cat Aida Herrerias - aida.herrerias@uab.cat Mariona Serra-Pagès - mariona.serra@uab.cat Jordi Roca-Ferrer - rocaferrer@gmail.com Laura Pujols - lpujols@clinic.ub.es Alberto Marco - alberto.marco@uab.cat César Picado - c.picado@clinic.ub.es Fernando de Mora - fernando.demora@uab.cat Corresponding author Open Access Published 12 November 2008 Received 18 April 2008 Accepted 12 November 2008 Respiratory Research 2008 9 72 doi 10.1186 1465-9921 -9-72 This article is available from http respiratory-research.com content 9 1 72 2008 Torres et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Despite its reported pro-inflammatory activity cyclooxygenase COX -2 has been proposed to play a protective role in asthma. Accordingly COX-2 might be down-regulated in the airway cells of asthmatics. This together with results of experiments to assess the impact of COX-2 blockade in