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Báo cáo y học: " Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma. | Respiratory Research BioMed Central Research Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma Benjamin A Raby 1 2 3 4 Kristel Van Steen5 Jessica Lasky-Su1 4 Kelan Tantisira1 2 3 4 Feige Kaplan6 and Scott T Weiss1 2 3 4 Address 1Channing Laboratory Department of Medicine Brigham and Women s Hospital Boston Massachusetts USA 2Division of Pulmonary and Critical Care Medicine Brigham and Women s Hospital Boston Massachusetts USA 3Harvard Medical School Boston Massachusetts USA 4Center for Genomic Medicine Brigham and Women s Hospital Boston Massachusetts USA 5Department of Oto-rhino-laryngology Department of Applied Mathematics and Computer Science University of Ghent Belgium and 6Departments of Human Genetics and Pediatrics McGill University Montreal Quebec Canada Email Benjamin A Raby - rebar@channing.harvard.edu Kristel Van Steen - kvansteen@gmail.com Jessica Lasky-Su - jessica.a.su@gmail.com KelanTantisira-rekgt@channing.harvard.edu Feige Kaplan - feige.kaplan@mcgill.ca ScottTWeiss-restw@channing.harvard.edu Corresponding author Open Access Published 20 July 2009 Received 31 March 2009 Respiratory Research 2009 10 67 doi 10.1186 1465-9921-10-67 Accepted 20 July 2009 This article is available from http respiratory-research.cOm content 10 1 67 2009 Raby et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Glucocorticoid function is dependent on efficient translocation of the glucocorticoid receptor GR from the cytoplasm to the nucleus of cells. Importin-13 IPO13 is a nuclear transport receptor that mediates nuclear entry of GR. In airway epithelial cells inhibition of IPO13 expression prevents nuclear entry of GR and abrogates anti-inflammatory effects of