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Báo cáo y học: " Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency. | BioMed Central Respiratory Research Open Access Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency David G Parr 1 Asger Dirksen2 Eeva Piitulainen3 Chunqin Deng4 Marion Wencker5 and Robert A Stockley6 Address Department of Respiratory Medicine University Hospitals of Coventry and Warwickshire Clifford Bridge Road Coventry CV2 2DX UK 2Gentofte Hospital Copenhagen University DK-2900 Hellerup Denmark 3Department of Respiratory Medicine University Hospital Malmo Sweden 4Talecris Biotherapeutics Inc. Research Triangle Park NC 27709 USA 5Talecris Biotherapeutics GmbH Lyoner Strasse 15 D-60528 Frankfurt am Main Germany and 6Lung Investigation Unit University Hospitals of Birmingham Edgbaston Birmingham B15 2TH UK Email David G Parr - david.parr@uhcw.nhs.uk Asger Dirksen - adi@dadlnet.dk Eeva Piitulainen - eeva.piitulainen@med.lu.se Chunqin Deng-cq.deng@talecris.com MarionWencker-marion.wencker@talecris.com RobertAStockley-r.a.stockley@bham.ac.uk Corresponding author Published 13 August 2009 Received 9 June 2009 Respiratory Research 2009 10 75 doi l0.ll86 l465-992l-l0-75 Accepted I3 August 2009 This article is available from http respiratory-research.cOm content l0 l 75 2009 Parr et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Computed tomography CT lung densitometry has been demonstrated to be the most sensitive and specific outcome measure for the assessment of emphysema-modifying therapy but the optimum densitometric index has yet to be determined and targeted sampling may be more sensitive than whole lung assessment. The EXAcerbations and CT scan as Lung Endpoints EXACTLE trial aimed to clarify .