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Báo cáo y học: " Anti-inflammatory effects of antibacterials on human bronchial epithelial cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Anti-inflammatory effects of antibacterials on human bronchial epithelial cells. | Respiratory Research BioMed Central Open Access Anti-inflammatory effects of antibacterials on human bronchial epithelial cells Gregor S Zimmermann1 Claus Neurohr1 Heidrun Villena-Hermoza1 Rudolf Hatz2 and Juergen Behr 1 Address Department of Internal Medicine I Division of Pulmonary Diseases Ludwig Maximilians University Klinikum Grosshadern Munich Germany and 2Division of Thoracic Surgery Ludwig-Maximilians-University Klinikum Grosshadern Munich Germany Email GregorSZimmermann-Gregor.Zimmermann@med.uni-muenchen.de Claus Neurohr - Claus.Neurohr@med.uni-muenchen.de Heidrun Villena-Hermoza - Heidrun.Villena@med.uni-muenchen.de Rudolf Hatz - Rudolf.Hatz@med.uni-muenchen.de Juergen Behr - Juergen.Behr@med.uni-muenchen.de Corresponding author Published 29 September 2009 Respiratory Research 2009 10 89 doi l0.ll86 l465-992l-l0-89 Received 13 March 2009 Accepted 29 September 2009 This article is available from http respiratory-research.cOm content 10 l 89 2009 Zimmermann et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human Bronchial epithelial cells hu-BEC have been claimed to play a significant role in the pathogenesis of chronic inflammatory airway diseases like COPD. In this context IL-8 and GM-CSF have been shown to be key cytokines. Some antibiotics which are routinely used to treat lower respiratory tract infections have been shown to exert additional immunomodulatory or anti-inflammatory effects. We investigated whether these effects can also be detected in hu-BEC. Methods Hu-BEC obtained from patients undergoing lung resections were transferred to airliquid-interface ALI culture. These cultures were incubated with cefuroxime CXM 10-62.5 mg l azithromycin AZM 0.1-1.5 mg l levofloxacin LVX l-8 mg