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Báo cáo y học: "Exercise-induced changes in interleukin-10 in patients with knee osteoarthritis: new perspectives"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Exercise-induced changes in interleukin-10 in patients with knee osteoarthritis: new perspectives? | Lems and den Uyl Arthritis Research Therapy 2010 12 131 http arthritis-research.eom content 12 4 131 EDITORIAL Exercise-induced changes in interleukin-10 in patients with knee osteoarthritis new perspectives Willem F Lems and Debby den Uyl See related research by Helmark etal. http arthritis-research.eom content 12 4 R126 Abstract Osteoarthritis OA of the knee is a common chronic disease leading to increased morbidity and reduced quality of life. Although exercise therapy has been shown to be beneficial for both pain and physical functioning its underlying mechanism is not fully understood. However a recent study found an exercise-induced increase in interleukin-10 levels to which anti-inflammatory and chondroprotective properties are ascribed in the peri- synovial fluid of patients with knee OA. These interesting results provide more insight into the effects of exercise in OA and need to be validated and confirmed. Hopefully the study offers a promising basis for further research. Osteoarthritis OA of the knee is a common chronic disease affecting more than half of older persons. Moreover owing to both aging and life-style factors its prevalence is expected to increase in the coming years. Undoubtedly OA may lead to increased morbidity and reduced quality of life in many older people. OA progresses slowly and for clinicians it is a well-known phenomena that although patients with OA suffer from chronic pain exacerbations may occur and these are associated with more pain low-grade inflammation and joint swelling. Unfortunately therapeutic options that interfere with the progression of OA have not yet been found. For that reason pain reduction with analgesic and antiinflammatory drugs and life-style interventions such as weight loss in adipose older persons and physical therapy are the treatment options for OA. Exercise therapy has Correspondence wf.lems@vumc.nl VU University Medical Centre Department of Rheumatology De Boelelaan 1117 1081 HV Amsterdam The .