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Báo cáo y học: " In-vivo kinetics of inhaled 5-Aminolevulinic acid-Induced Protoporphyrin IX fluorescence in bronchial tissue"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " In-vivo kinetics of inhaled 5-Aminolevulinic acid-Induced Protoporphyrin IX fluorescence in bronchial tissue. | Respiratory Research BioMed Central Open Access In-vivo kinetics of inhaled 5-Aminolevulinic acid-Induced Protoporphyrin IX fluorescence in bronchial tissue Hubert Hautmann 1 Josef P Pichler2 Herbert Stepp2 Reinhold Baumgartner2 Fernando Gamarra3 and Rudolf M Huber3 Address 1Medizinische Klinik I Klinikum rechts der Isar Technische Universitat D-81675 Munich Germany 2Laser-Forschungslabor an der Urologischen Klinik Grofihadern D-81377 Munich Germany and 3Medizinische Klinik-Innenstadt Klinikum der Ludwig-Maximilians-Universitat D-80336 Munich Germany Email Hubert Hautmann - hautmann@web.de Josef P Pichler - josefpeterpichler@yahoo.de Herbert Stepp - herbert.stepp@med.uni-muenchen.de Reinhold Baumgartner-reinhold.baumgartner@med.uni-muenchen.de Fernando Gamarra-gamarra@med.uni-muenchen.de Rudolf M Huber - huber@med.uni-muenchen.de Corresponding author Published 19 April 2007 Received 26 July 2006 Respiratory Research 2007 8 33 doi 10.1186 1465-9921-8-33 Accepted 19 April 2007 This article is available from http respiratory-research.cOm content 8 1 33 2007 Hautmann et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In the diagnosis of early-stage lung cancer photosensitizer-enhanced fluorescence bronchoscopy with inhaled 5-aminolevolinic acid 5-ALA increases sensitivity when compared to white-light bronchoscopy. This investigation was to evaluate the in vivo tissue pharmacokinetics of inhaled 5-ALA within the bronchial mucosa in order to define the time optimum for its application prior to bronchoscopy. Methods Patients with known or suspected bronchial carcinoma were randomized to receive 200 mg 5-ALA via inhalation 1 2 3