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Báo cáo y học: " Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD. | Respiratory Research BioMed Central Research Open Access Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD Agne Babusyte1 Kristina Stravinskaite2 Jolanta Jeroch1 Jan Lotvall3 Raimundas Sakalauskas2 and Brigita Sitkauskiene 1 2 Address Laboratory of Pulmonology Institute for Biomedical Research Kaunas University of Medicine Eiveniu 4 LT-50009 Kaunas Lithuania 2Department of Pulmonology and Immunology Kaunas University of Medicine Eiveniu 2 LT-50009 Kaunas Lithuania and 3The Lung Pharmacology Group Department of Respiratory Medicine and Allergology Institute of Internal Medicine Goteborg University Guldhedsgatan 10A 413 46 Gothenburg Sweden Email Agne Babusyte - agne.babusyte@gmail.com Kristina Stravinskaite - kristina.stravinskaite@gmail.com Jolanta Jeroch - jolanta.jeroch@kmuk.lt Jan Lotvall - jan.lotvall@gu.se Raimundas Sakalauskas - raimundas.sakalauskas@kmuk.lt Brigita Sitkauskiene - brigita.sitkauskiene@kmuk.lt Corresponding author Published 14 November 2007 Received 21 June 2007 Respiratory Research 2007 8 81 doi l0.ll86 l465-992l-8-8l Accepted I4 November 2007 This article is available from http respiratory-research.com content 8 l 8l 2007 Babusyte et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Smoking activates and recruits inflammatory cells and proteases to the airways. Matrix metalloproteinase MMP -l2 may be a key mediator in smoke induced emphysema. However the influence of smoking and its cessation on airway inflammation and MMP-l2 expression during COPD is still unknown. We aimed to analyse airway inflammatory cell patterns in induced sputum IS and bronchoalveolar lavage BAL from COPD patients who are active smokers and who have ceased smoking 2