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Báo cáo y học: " (R)-albuterol decreases immune responses: role of activated T cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " (R)-albuterol decreases immune responses: role of activated T cells. | Respiratory Research BioMed Central Research R -albuterol decreases immune responses role of activated T cells Marcela A Ferrada11 2 Erin L Gordon12 Kai Yu Jen1 2 Hong Zhen He1 2 Xin Lu2 4 Leesa M Barone5 Sepideh Amirifeli1 2 David L Perkins2 3 and Patricia W Finn 1 2 Open Access Address 1Pulmonary and Critical Care Division University of California San Diego La Jolla USA 2Department of Medicine University of California San Diego La Jolla USA 3Department of Surgery University of California San Diego La Jolla USA 4Department of Family and Preventive Medicine University of California San Diego La Jolla USA and 5Sepracor Inc. Marlborough USA Email Marcela A Ferrada - marceferrada@yahoo.com Erin L Gordon - elgordon@ucsd.edu Kai Yu Jen - kjen@ucsd.edu Hong Zhen He - hzhe@ucsd.edu Xin Lu - xinlu@ucsd.edu Leesa M Barone - leesa.barone@sepracor.com Sepideh Amirifeli - asepideh@hotmail.com David L Perkins - davperkins@ucsd.edu Patricia W Finn - pwfinn@ucsd.edu Corresponding author tEqual contributors Published 14 January 2008 Received 28 April 2007 Respiratory Research 2008 9 3 doi 10.1186 1465-9921-9-3 Accepted I4 January 2008 This article is available from http respiratory-research.cOm content 9 1 3 2008 Ferrada et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Racemic albuterol is an equimolar mixture of two isomers R and S . Whether R and S isomers and the combination of both exert different effects in immune activation is not well defined. We analyzed the effects of R S -albuterol R -albuterol and S -albuterol in a murine model of allergic pulmonary inflammation and in activated T cells. Mice C57BL 6 sensitized and aerosol challenged .