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Báo cáo y học: " Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?. | Respiratory Research BioMed Central Research Open Access Heme oxygenase-l prevents smoke induced B-cell infiltrates a role for regulatory T cells Corry-Anke Brandsma 1 2 Machteld N Hylkema2 Barry WA van der Strate1 2 Dirk-Jan Slebos1 Marjan A Luinge1 2 Marie Geerlings1 2 Wim Timens2 Dirkje S Postma1 and Huib AM Kerstjens1 Address Department of Pulmonary Diseases University Medical Center Groningen University of Groningen P.O. Box 30.001 9700 RB Groningen The Netherlands and 2Department of Pathology University Medical Center Groningen University of Groningen P.O. Box 30.001 9700 RB Groningen The Netherlands Email Corry-Anke Brandsma - c.a.brandsma@path.umcg.nl Machteld N Hylkema - m.n.hylkema@path.umcg.nl Barry WA van der Strate - b.w.a.van.der.strate@med.umcg.nl Dirk-Jan Slebos - d.j.slebos@int.umcg.nl Marjan A Luinge - m.luinge@path.umcg.nl Marie Geerlings - m.geerlings@path.umcg.nl WimTimens - w.timens@path.umcg.nl Dirkje S Postma - d.s.postma@int.umcg.nl Huib AM Kerstjens - h.a.m.kerstjens@int.umcg.nl Corresponding author Published 6 February 2008 Received 10 July 2007 Respiratory Research 2008 9 17 doi 10.1186 1465-9921-9-17 Accepted 6 February 2008 This article is available from http respiratory-research.cOm content 9 1 17 2008 Brandsma et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Smoking is the most important cause for the development of COPD. Since not all smokers develop COPD it is obvious that other factors must be involved in disease development. We hypothesize that heme oxygenase-1 HO-1 a protective enzyme against oxidative stress and inflammation is insufficiently upregulated in COPD. The effects of HO-1 modulation on cigarette smoke induced inflammation and emphysema were tested in