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Báo cáo y học: " Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice. | Respiratory Research BioMed Central Research Open Access Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice Sofia Jonasson 1 Linda Swedin2 Maria Lundqvist1 Goran Hedenstierna1 Sven-Erik Dahlén2 and Josephine Hjoberg1 Address department of Medical Sciences Clinical Physiology Uppsala University Uppsala Sweden and 2The National Institute of Environmental Medicine Division of Physiology Karolinska Institutet Stockholm Sweden Email Sofia Jonasson - sofia.jonasson@medsci.uu.se Linda Swedin - linda.swedin@ki.se Maria Lundqvist - maria.lundqvist@medsci.uu.se Goran Hedenstierna - goran.hedenstierna@medsci.uu.se Sven-Erik Dahlén - sven-erik.dahlen@ki.se Josephine Hjoberg - hjoberg@medsci.uu.se Corresponding author Published 28 February 2008 Respiratory Research 2008 9 23 doi l0.ll86 l465-992l -9-23 Received 3 January 2008 Accepted 28 February 2008 This article is available from http respiratory-research.eom content 9 l 23 2008 Jonasson et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Deep inspirations DI have bronchodilatory and bronchoprotective effects in healthy human subjects but these effects appear to be absent in asthmatic lungs. We have characterized the effects of DI on lung mechanics during mechanical ventilation in healthy mice and in a murine model of acute and chronic airway inflammation. Methods Balb c mice were sensitized to ovalbumin OVA and exposed to nebulized OVA for l week or l2 weeks. Control mice were challenged with PBS. Mice were randomly selected to receive DI which were given twice during the minute before assessment of lung mechanics. Results DI protected against bronchoconstriction of central airways in healthy mice and