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Báo cáo y học: "Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia. | Respiratory Research BioMed Central Research Open Access Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia Hisashi Suzuki James C Hogg and Stephan F van Eeden Address The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research St. Paul s Hospital University of British Columbia Room 166 1081 Burrard Street Vancouver British Columbia V6Z 1Y6 Canada Email Hisashi Suzuki - hsuzuki-jpn@umin.ac.jp James C Hogg - JHogg@mrl.ubc.ca Stephan F van Eeden - SVaneeden@mrl.ubc.ca Corresponding author Published 3 March 2008 Received 15 October 2007 Respiratory Research 2008 9 25 doi 10.1186 1465-9921 -9-25 Accepted 3 March 2008 This article is available from http respiratory-research.cOm content 9 1 25 2008 Suzuki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bone marrow BM -derived progenitor cells have been shown to have the potential to differentiate into a diversity of cell types involved in tissue repair. The characteristics of these progenitor cells in pneumonia lung is unknown. We have previously shown that Streptococcus pneumoniae induces a strong stimulus for the release of leukocytes from the BM and these leukocytes preferentially sequester in the lung capillaries. Here we report the behavior of BM-derived lineage negative progenitor cells Lin- PCs during pneumococcal pneumonia using quantum dots QDs nanocrystal fluorescent probes as a cell-tracking technique. Methods Whole BM cells or purified Lin- PCs harvested from C57 BL6 mice were labeled with QDs and intravenously transfused into pneumonia mice infected by intratracheal instillation of Streptococcus pneumoniae. Saline was instilled for control. The recipients .