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Báo cáo y học: "Time course of airway remodelling after an acute chlorine gas exposure in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Time course of airway remodelling after an acute chlorine gas exposure in mice. | Respiratory Research BioMed Central Open Access Time course of airway remodelling after an acute chlorine gas exposure in mice Stephanie A Tuck1 David Ramos-Barbón2 Holly Campbell1 Toby McGovern1 Harry Karmouty-Quintana1 and James G Martin 1 Address 1Meakins-Christie Laboratories McGill University Montreal Canada and 2Complejo Hospitalario Universitario Juan Canalejo A Coruna Spain Email Stephanie A Tuck - stephanie_tuck@hotmail.com David Ramos-Barbón - david.ramos-barbon@canalejo.org Holly Campbell - holly@campbell.as Toby McGovern - toby.mcgovern@mail.mcgill.ca Harry Karmouty- Quintana - harry.karmoutyquintana@mcgill.ca James G Martin - james.martin@mcgill.ca Corresponding author Published 14 August 2008 Received 24 August 2007 Respiratory Research 2008 9 61 doi l0.ll86 l465-992l-9-6l Accepted I4 August 2008 This article is available from http respiratory-research.cOm content 9 l 6l 2008 Tuck et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Accidental chlorine Cl2 gas inhalation is a common cause of acute airway injury. However little is known about the kinetics of airway injury and repair after Cl2 exposure. We investigated the time course of airway epithelial damage and repair in mice after a single exposure to a high concentration of Cl2 gas. Mice were exposed to 800 ppm Cl2 gas for 5 minutes and studied from 12 hrs to 10 days post-exposure. The acute injury phase after Cl2 exposure 24 hrs post-exposure was characterized by airway epithelial cell apoptosis increased TUNEL staining and sloughing elevated protein in bronchoalveolar lavage fluid and a modest increase in airway responses to methacholine. The repair phase after Cl2 .