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Báo cáo y học: "Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model. | García et al. Arthritis Research Therapy 2010 12 R224 http arthritis-research.eom content 12 6 R224 RESEARCH ARTICLE Open Access Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K BxN serum-transfer arthritis model 1 2 3 1.4 1 Samuel García Jeronimo Forteza Carlos López-Otin Juan J Gómez-Reino 1 Antonio Gonzalez Carmen Conde1 Abstract Introduction Rheumatoid arthritis is an autoimmune disease in which joint inflammation leads to progressive cartilage and bone erosion. Matrix metalloproteinases MMPs implicated in homeostasis of the extracellular matrix play a central role in cartilage degradation. However the role of specific MMPs in arthritis pathogenesis is largely unknown. The aim of the present study was to investigate the role of Mmp-8 collagenase-2 in an arthritis model. Methods Arthritis was induced in Mmp8-deficient and wildtype mice by K BxN serum transfer. Arthritis severity was measured by a clinical index and ankle sections were scored for synovial inflammation cartilage damage and bone erosion. cDNA microarray analysis real-time PCR and western blot were performed to identify differential changes in gene expression between mice lacking Mmp8 and controls. Results Mmp8 deficiency increased the severity of arthritis although the incidence of disease was similar in control and deficient mice. Increased clinical score was associated with exacerbated synovial inflammation and bone erosion. We also found that the absence of Mmp8 led to increased expression of IL-1b pentraxin-3 PTX3 and prokineticin receptor 2 PROKR2 in arthritic mice joints. Conclusions Lack of Mmp-8 is accompanied by exacerbated synovial inflammation and bone erosion in the K BxN serum-transfer arthritis model indicating that this Mmp has a protective role in arthritis. Introduction Rheumatoid arthritis RA is a chronic autoimmune disease characterized by joint inflammation and progressive destruction of cartilage and bone. Current knowledge of joint .