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Báo cáo y học: " Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study. | Pineda et al. Arthritis Research Therapy 2011 13 R4 http arthritis-research.eom content 13 1 R4 RESEARCH ARTICLE Open Access Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia an ultrasound controlled study s r I z r D I I s 1 t I I I I r h ỉ -7z I I s 1 ir rr i2 c z I s z 3 D I r D z I k I I z 7 I_I z r fz t I 17 74 k r f- I I_n 7 7 f s 75 Carlos Pineda Luis M Amezcua-Guerra Carla Solano Pedro Rodriguez-nenriquez Cristina nernandez-Diaz Angelica Vargas6 Fritz Hofmann5 Marwin Gutierrez7 Abstract Introduction In this study we aimed to investigate ultrasonographic US changes suggestive of gouty arthritis in the hyaline cartilage joints and tendons from asymptomatic individuals with hyperuricemia. Methods We conducted a cross-sectional controlled study including US examinations of the knees and first metatarsal-phalangeal joints first MTPJs as well as of the tendons and enthesis of the lower limbs. Differences were estimated by c2 or unpaired t-tests as appropriate. Associations were calculated using the Spearman s correlation coefficient rank test. Results Fifty asymptomatic individuals with hyperuricemia and 52 normouricemic subjects were included. Hyperechoic enhancement of the superficial margin of the hyaline cartilage double contour sign was found in 25 of the first MTPJs from hyperuricemic individuals in contrast to none in the control group P 0.0001 . Similar results were found on the femoral cartilage 17 versus 0 P 0.0001 . Patellar enthesopathy 12 versus 2.9 P 0.01 and tophi 6 versus 0 P 0.01 as well as Achilles enthesopathy 15 versus 1.9 P 0.0007 were more frequent in hyperuricemic than in normouricemic individuals. Intra-articular tophi were found in eight hyperuricemic individuals but in none of the normouricemic subjects P 0.003 . Conclusions These data demonstrate that morphostructural changes suggestive of gouty arthritis induced by chronic hyperuricemia frequently occur in both intra- and .