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Báo cáo y học: "Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study. | Satoh et al. Arthritis Research Therapy 2011 13 R73 http arthritis-research.eom content 13 3 R73 RESEARCH ARTICLE Open Access Frequent coexistence of anti-topoisomerase I and anti-UIRNP autoantibodies in African American patients associated with mild skin involvement a retrospective clinical study 1.2 11 3 13 3 Minoru Satoh Malgorzata E Krzyszczak Yi Li Angela Ceribelli Steven J Ross Edward KL Chan Mark S Segal4 Michael R Bubb 1 Eric S Sobel1 2 and Westley H Reeves1 2 Abstract Introduction The presence of anti-topoisomerase I topo I antibodies is a classic scleroderma SSc marker presumably associated with a unique clinical subset. Here the clinical association of anti-topo I was reevaluated in unselected patients seen in a rheumatology clinic setting. Methods Sera from the initial visit in a cohort of unselected rheumatology clinic patients n 1 966 including 434 systemic lupus erythematosus SLE 119 SSc 85 polymyositis dermatomyositis PM DM were screened by radioimmunoprecipitation. Anti-topo I-positive sera were also tested with immunofluorescence and RNA immunoprecipitation. Results Twenty-five 15 Caucasian eight African American two Latin anti-topo I positive patients were identified and all except one met the ACR SSc criteria. Coexistence of other SSc autoantibodies was not observed except for anti-U1RNP in six cases. When anti-topo I alone versus anti-topo I U1RNP groups were compared African American 21 vs. 67 overlap with SLE 0 vs. 50 P 0.009 or PM DM 0 vs. 33 P 0.05 or elevated creatine phosphokinase CPK P 0.07 were more common in the latter group. In comparison of anti-topo I-positive Caucasians versus African Americans the latter more frequently had anti-U1RNP 13 vs. 50 mild no skin changes 14 vs. 63 P 0.03 and overlap with SLE 0 vs. 38 P 0.03 and PM DM 0 vs. 25 P 0.05 . Conclusions Anti-topo I detected by immunoprecipitation in unselected rheumatology patients is highly specific for SSc. Anti-topo I coexisting with anti-U1RNP in African American patients