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Báo cáo y học: "Marked stem cell factor expression in the airways of lung transplant recipients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Marked stem cell factor expression in the airways of lung transplant recipients. | Respiratory Research BioMed Central Research Open Access Marked stem cell factor expression in the airways of lung transplant recipients Carla A Da Silva1 Mélanie Adda2 Marc Stern3 Frédéric de Blay1 Nelly Frossard1 and Dominique Israel-Biet 2 4 Address 11EA 3771 Inflammation and environment in asthma . Faculté de Pharmacie BP 60024 67401 Illkirch Cedex France 2UPRES EA 220. Université Paris V. UFR Biomédicale des Saints-Pères 45 rue des Saints-Pères 75006 Paris France 3Service de Pneumologie. CMC Foch 40 rue Worth 92151 Suresnes Cedex France and 4Service de Pneumologie. Hôpital Européen Georges Pompidou Faculté de Médecine Paris V 20 rue Leblanc 75015 Paris France Email Carla A Da Silva - carla.dasilva@pharma.u-strasbg.fr Mélanie Adda - adda@biomedicale.univ-paris5.fr Marc Stern - m.stern@hopital-foch.org Frédéric de Blay - frederic.deblay@chru-strasbourg.fr Nelly Frossard - nelly.frossard@pharma.u-strasbg.fr Dominique Israel-Biet - dib.laennec@invivo.edu Corresponding author Published 16 June 2006 Received 28 June 2005 Respiratory Research 2006 7 90 doi l0.ll86 l465-992l-7-90 Accepted 16 June 2006 This article is available from http respiratory-research.cOm content 7 l 90 2006 Da Silva et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Airways repair is critical to lung function following transplantation. We hypothesised that the stem cell factor SCF could play a role in this setting. Methods We studied 9 lung transplant recipients LTx recipients during their first year postgraft and evaluated SCF mRNA expression in bronchial biopsy specimens using on-line fluorescent PCR and SCF protein levels in bronchoalveolar lavage BAL and serum using ELISA. The expression of SCF receptor Kit was assessed using