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Báo cáo y học: " Neurotrophins in bronchial asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Neurotrophins in bronchial asthma. | Available online http respiratory-research.eom content 2 5 265 Commentary Neurotrophins in bronchial asthma Harald Renz Department of Clinical Chemistry and Molecular Diagnostics Central Laboratory Philipps University Marburg Germany Correspondence Harald Renz MD Chairman and Head of the Department of Clinical Chemistry and Molecular Diagnostics Central Laboratory Hospital of the Philipps University Baldingerstrasse D-35033 Marburg Germany. Tel 49 6421 2866234 5 fax 49 6421 2865594 e-mail renzh@post.med.uni-marburg.de o 3 I Received 27 April 2001 Revisions requested 4 May 2001 Revisions received 21 May 2001 Accepted 11 June 2001 Published 12 July 2001 Respir Res 2001 2 265-268 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Allergic bronchial asthma BA is characterized by chronic airway inflammation development of airway hyperreactivity and recurrent reversible airway obstruction. T-helper 2 cells and their products have been shown to play an important role in this process. In contrast the mechanisms by which immune cells interact with the cells residing in lung and airways such as neurons epithelial or smooth muscle cells still remains uncertain. Sensory and motor neurons innervating the lung exhibit a great degree of functional plasticity in BA defined as neuronal plasticity . These neurons control development of airway hyperresponsiveness and acute inflammatory responses resulting in the concept of neurogenic inflammation . Such quantitative and or qualitative changes in neuronal functions are mediated to a great extent by a family of cytokines the neurotrophins which in turn are produced by activated immune cells among others in BA. We have therefore developed the concept that neurotrophins such as nerve growth factor and brain-derived neurotrophic factor link pathogenic events in BA to dysfunctions of the immune and nervous system. Keywords bronchial asthma neurogenic inflammation neuronal plasticity neurotrophins Introduction BA is