Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis. | Available online http respiratory-research.eom content 3 1 9 Commentary Anorexigen-induced pulmonary hypertension and the serotonin 5-HT hypothesis lessons for the future in pathogenesis Saadia Eddahibi and Serge Adnot INSERM U492 Département de Physiologie Hôpital H. Mondor Créteil France Correspondence Serge Adnot INSERM U492 Département de Physiologie Faculté de Médecine de Créteil 94010 Créteil France. Fax 33 1 48 98 17 77 e-mail serge.adnot@creteil.inserm.fr Received 25 June 2001 Revisions requested 24 July 2001 Revisions received 28 August 2001 Accepted 7 September 2001 Published 20 November 2001 Respir Res 2002 3 9 2002 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Epidemiological studies have established that fenfluramine D-fenfluramine and aminorex but not other appetite suppressants increase the risk of primary pulmonary hypertension PH . One current hypothesis suggests that fenfluramine-like medications may act through interactions with the serotonin 5-hydroxytryptamine 5-HTI transporter 5-HTT located on pulmonary artery smooth muscle cells and responsible for the mitogenic action of 5-HT. Anorexigens may contribute to PH by boosting 5-HT levels in the bloodstream directly stimulating smooth muscle cell growth or altering 5-HTT expression. We suggest that individuals with a high basal level of 5-HTT expression related to the presence of the long 5-HTT gene promoter variant may be particularly susceptible to one or more of these potential mechanisms of appetite-suppressant-related PH. Keywords anorexigens appetite suppressants pulmonary hypertension pulmonary vascular smooth muscle cells serotonin transporter Introduction Appetite suppressant use is now considered an important risk factor for the development of primary PH. An association between the anorexigen aminorex and PH was first reported in the 1960s and aminorex was withdrawn from the market in 1972 1 . In the 1980s fenfluramine use was linked to primary PH and .