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Báo cáo y học: "Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D. | Respiratory Research BioMed Central Research Open Access Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins SP -A and SP-D Shanjana Awasthi 1 D Mitchell Magee2 3 and Jacqueline J Coalson1 Address department of Pathology University of Texas Health Science Center at San Antonio San Antonio TX USA department of Microbiology and Immunology University of Texas Health Science Center at San Antonio San Antonio TX USA and 3Center for Biomedical Inventions University of Texas Southwestern Medical Center Dallas TX USA Email Shanjana Awasthi - awasthis@uthscsa.edu D Mitchell Magee - mitch.magee@utsouthwestern.edu Jacqueline J Coalson - coalson@uthscsa.edu Corresponding author Published 10 December 2004 Respiratory Research 2004 5 28 doi l0.ll86 l465-992l-5-28 Received 19 August 2004 Accepted l0 December 2004 This article is available from http respiratory-research.Com content 5 l 28 2004 Awasthi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Coccidioidomycosis or Valley Fever is caused by Coccidioides in Southwest US and Central America. Primary pulmonary infection is initiated by inhalation of air-borne arthroconidia. Since lung is the first organ that encounters arthroconidia different components of the pulmonary innate immune system may be involved in the regulation of host defense. Pulmonary surfactant proteins SP -A and SP-D have been recognized to play an important role in binding and phagocytosis of various microorganisms but their roles in Coccidioides infection are not known. Methods In this study we studied the changes in amounts of pulmonary SP-A SP-D and phospholipid in murine model of Coccidioides posadasii infection and binding of SP-A and SP-D to .