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Báo cáo y học: "ATP-binding cassette (ABC) transporters in normal and pathological lung"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "ATP-binding cassette (ABC) transporters in normal and pathological lung. | Respiratory Research BioMed Central Review ATP-binding cassette ABC transporters in normal and pathological lung Margaretha van der Deen1 Elisabeth GE de Vries1 Wim Timens3 Rik J Scheper4 Hetty Timmer-Bosscha1 and Dirkje S Postma 2 Open Access Address University Medical Center Groningen Department of Internal Medicine Medical Oncology Hanzeplein 1 9713 GZ Groningen The Netherlands 2Department of Pulmonary Medicine Hanzeplein 1 9713 GZ Groningen The Netherlands 3Department of Pathology and Laboratory Medicine Hanzeplein 1 9713 GZ Groningen The Netherlands and 4Free University Department of Pathology Boelelaan 1117 1081 HV Amsterdam The Netherlands Email Margaretha van der Deen - m.van.der.deen@int.umcg.nl Elisabeth GE de Vries - e.g.e.de.vries@int.umcg.nl Wim Timens - w.timens@path.umcg.nl Rik J Scheper - rj.scheper@vumc.nl Hetty Timmer-Bosscha - h.timmer-bosscha@int.umcg.nl Dirkje S Postma - d.s.postma@int.umcg.nl Corresponding author Published 20 June 2005 Respiratory Research 2005 6 59 doi 10.1186 1465-9921 -6-59 Received 04 April 2005 Accepted 20 June 2005 This article is available from http respiratory-research.com content 6 1 59 2005 van der Deen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract ATP-binding cassette ABC transporters are a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes in an energy-dependent manner. Many ABC transporters such as P-glycoprotein P-gp multidrug resistance-associated protein 1 MRP1 and breast cancer resistance protein BCRP are highly expressed in bronchial epithelium. This review aims to give new insights in the possible functions of ABC molecules in the lung in view of their expression in different cell types. .