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Báo cáo khoa học: " Identification of factor XI deficiency in Holstein cattle in Turkey"

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú y đề tài: Identification of factor XI deficiency in Holstein cattle in Turkey. | Acta Veterinaria Scandinavica BioMed Central Open Access Identification of factor XI deficiency in Holstein cattle in Turkey Hasan Meydan 1 Mehmet A Yildiz1 Fulya Ozdil2 Yasemin Gedik1 and Ceyhan Ozbeyaz3 Address 1Ankara University Faculty of Agriculture Animal Sciences 06110 Ankara Turkey 2Selẹuk University Faculty of Agriculture Animal Sciences 42075 Konya Turkey and 3Ankara University Faculty of Veterinary Medicine 06110 Ankara Turkey Email Hasan Meydan - hasan_meydan@hotmail.com Mehmet A Yildiz - mayildiz@agri.ankara.edu.tr Fulya Ozdil - fulyaozdil@selcuk.edu.tr Yasemin Gedik - ygedik@agri.ankara.edu.tr Ceyhan Ozbeyaz - ozbeyaz@veterinary.ankara.edu.tr Corresponding author Published 22 January 2009 Received 31 October 2008 . _ . r. J - . r . r Accepted 22 January 2009 Acta Veterinaria Scandinavica 2009 51 5 doi l0.ll86 l75l-0l47-5l-5 This article is available from http www.actavetscand.cOm content 5l l 5 2009 Meydan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Factor XI FXI is a plasma protein that participates in the formation of blood clots. Factor XI deficiency is autosomal recessive hereditary disorder that may be associated with excess bleeding in Holstein cattle. Methods In this study 225 Holstein cows reared in Turkey were screened in order to identify FXI genotypes. DNA extractions were obtained from the fresh blood of the cows. Amplicons of FXI exon 12 were obtained by Polymerase Chain Reaction PCR and analyzed by 2 agarose gel electrophoresis stained with ethidium bromide. Additionally all cows were confirmed by DNA sequencing to determine whether or not there was a mutant allele. Results Carriers of the FXI deficiency have two DNA fragments of 320 bp and 244 bp in size. The .