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Báo cáo y học: " Reactivation from latency displays HIV particle budding at plasma membrane, accompanying CD44 upregulation and recruitment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " Reactivation from latency displays HIV particle budding at plasma membrane, accompanying CD44 upregulation and recruitment. | Retrovirology BioMed Central Open Access Short report Reactivation from latency displays HIV particle budding at plasma membrane accompanying CD44 upregulation and recruitment Mari Suyama1 Eriko Daikoku2 Toshiyuki Goto3 Kouichi Sano2 and Yuko Morikawa 1 Address 1Kitasato University Shirokane 5-9-1 Minato-ku Tokyo 108-8641 Japan 2Osaka Medical College Daigaku-cho 2-7 Takatsuki Osaka 569-8686 Japan and 3School of Health Science Faculty of Medicine Kyoto University Kawaraha-cho 53 Shogoin Sakyo-ku Kyoto 606-8507 Japan Email Mari Suyama - maris@lisci.kitasato-u.ac.jp Eriko Daikoku - edaikoku@art.osaka-med.ac.jp Toshiyuki Goto - tgoto@hs.med.kyoto-u.ac.jp Kouichi Sano - ksano@art.osaka-med.ac.jp Yuko Morikawa - morikawa@lisci.kitasato-u.ac.jp Corresponding author Published 13 July 2009 Received 2 March 2009 Retrovirology 2009 6 63 doi 10.1186 1742-4690-6-63 Accepted 13 July 2009 This article is available from http www.retrovirology.cOm content 6 1 63 2009 Suyama et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background It has been accepted that HIV buds from the cell surface in T lymphocytes whereas in macrophages it buds into intracellular endosomes. Recent studies on the other hand suggest that HIV preferentially buds from the cell surface even in monocytic cells. However most studies are based on observations in acutely infected cells and little is known about HIV budding concomitant with reactivation from latency. Such studies would provide a better understanding of a reservoir for HIV. Results We observed HIV budding in latently infected T lymphocytic and monocytic cell lines following TNF-a stimulation and examined the .