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Báo cáo y học: " The utilization of humanized mouse models for the study of human retroviral infections"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: The utilization of humanized mouse models for the study of human retroviral infections. | Retrovirology BioMed Central Open Access The utilization of humanized mouse models for the study of human retroviral infections Rachel Van Duynef1 Caitlin Pedatit2 Irene Guendel2 Lawrence Carpio2 Kylene Kehn-Hall2 Mohammed Saifuddin3 and Fatah Kashanchi 2 Address Microbiology Immunology and Tropical Medicine Program The George Washington University School of Medicine Washington DC 20037 USA 2Department of Microbiology Immunology and Tropical Medicine The George Washington University School of Medicine Washington DC 20037 USA and 3CONRAD Eastern Virginia Medical School 1911 Fort Myer Drive Suite 900 Arlington VA 22209 USA Email Rachel Van Duyne - bcmrvv@gwumc.edu Caitlin Pedati - bcmcsp@gwumc.edu Irene Guendel - mtmixg@gwumc.edu Lawrence Carpio - lawrence.carpio@gmail.com Kylene Kehn-Hall - bcmkwk@gwumc.edu Mohammed Saifuddin - msaifuddin@conrad.org Fatah Kashanchi - bcmfxk@gwumc.edu Corresponding author fEqual contributors Published 12 August 2009 Received 24 March 2009 Accepted 12 August 2009 Retrovirology 2009 6 76 doi l0.l 186 1742-4690-6-76 This article is available from http www.retrovirology.cOm content 6 1 76 2009 Van Duyne et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The development of novel techniques and systems to study human infectious diseases in both an in vitro and in vivo settings is always in high demand. Ideally small animal models are the most efficient method of studying human afflictions. This is especially evident in the study of the human retroviruses HIV-1 and HTLV-1 in that current simian animal models though robust are often expensive and difficult to maintain. Over the past two decades the construction of humanized animal models through the transplantation and engraftment of .