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Báo cáo y học: " Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes. | Retrovirology BioMed Central Research Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes Tamara Bar-Magen1 Richard D Sloan1 Verena H Faltenbacher1 Daniel A Donahue1 2 Bjorn D Kuhl1 3 Maureen Oliveira1 Hongtao Xu1 and Mark A Wainberg 1 2 3 Address 1McGill University AIDS Centre Lady Davis Institute-Jewish General Hospital Montreal Quebec Canada - Department of Microbiology and Immunology McGill University Montreal Quebec H3A 2T5 Canada and 3Division of Experimental Medicine McGill University Montreal Quebec H3A 2T5 Canada Email Tamara Bar-Magen - tamara.bar-magen@mail.mcgill.ca Richard D Sloan - richard.sloan@mail.mcgill.ca Verena H Faltenbacher - v.faltenbacher@web.de Daniel A Donahue - daniel.donahue@mail.mcgill.ca Bjorn D Kuhl - Bjorn.kuhl@mail.mcgill.ca Maureen Oliveira - moliveira@ldi.jgh.mcgill.ca Hongtao Xu - hongtaoxu_00@yahoo.com Mark AWainberg - mark.wainberg@mcgill.ca Corresponding author Open Access Published II November 2009 Received 16 June 2009 Accepted 1 1 November 2009 Retrovirology 2009 6 103 doi 10.1186 1742-4690-6- 103 This article is available from http www.retrovirology.com content 6 1 103 2009 Bar-Magen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Integrase inhibitors are currently being incorporated into highly active antiretroviral therapy HAART . Due to high HIV variability integrase inhibitor efficacy must be evaluated against a range of integrase enzymes from different subtypes. Methods This study compares the enzymatic activities of HIV-1 integrase from subtypes B and C as well as susceptibility to various integrase inhibitors in vitro. The catalytic activities of both enzymes were analyzed in regard to each of 3 processing and strand transfer