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Bóa cáo y học: "Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury. | Available online http ccforum.eom content 10 3 R71 Research Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury Sascha Meyer Sven Gottschling Ali Baghai Donald Wurm and Ludwig Gortner Department of Neonatology and Pediatric Intensive Care University Children s Hospital of Saarland 66421 Homburg Germany Corresponding author Sascha Meyer sascha.meyer@uniklinikum-saarland.de Received 10 Feb 2006 Revisions requested 27 Mar 2006 Revisions received 6 Apr 2006 Accepted 1 2 Apr 2006 Published 5 May 2006 Critical Care 2006 10 R71 doi 10.1186 cc4917 This article is online at http ccforum.com content 10 3 R71 2006 Meyer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The aim of this study was to assess the efficacy of arginine-vasopressin AVP as a rescue therapy in catecholamine-refractory septic and non-septic shock in extremely low birth weight ELBW infants with acute renal injury. Methods Prospective assessment of AVP therapy in three ELBW infants with catecholamine-refractory septic shock and acute renal injury mean birth weight 600 30 g and three ELBW infants with non-septic shock and acute renal injury mean birth weight 770 110 g at a University hospital. The main outcome measures were restoration of blood pressure with adequate organ perfusion and survival at discharge. Results In all three ELBW infants with catecholamine-resistant septic shock systemic arterial blood pressure increased substantively with restoration of urine output after AVP administration dosage 0.035 to 0.36 U kg h length 70 21 hours . In the three ELBW infants with non-septic shock only a transient stabilization in mean arterial