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Báo cáo y học: "Generation of a single pulmonary pressure-volume curve does not durably affect oxygenation in patients with acute respiratory distress syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Generation of a single pulmonary pressure-volume curve does not durably affect oxygenation in patients with acute respiratory distress syndrome. | Available online http ccforum.eom content 10 3 R85 Research Generation of a single pulmonary pressure-volume curve does not durably affect oxygenation in patients with acute respiratory distress syndrome Antoine Roch Jean-Marie Forel Didier Demory Jean-Michel Arnal Stéphane Donati Marc Gainnier and Laurent Papazian Service de Réanimation Médicale Hôpitaux Sud Marseille France Corresponding author Antoine Roch antoine.roch@ap-hm.fr Received 4 Mar 2006 Revisions requested 27 Mar 2006 Revisions received 7 Apr 2006 Accepted 3 May 2006 Published 1 Jun 2006 Critical Care 2006 10 R85 doi 10.1186 cc4936 This article is online at http ccforum.com content 10 3 R85 2006 Roch et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction It is possible that taking a static pressure-volume PV measurement could durably affect oxygenation and thus interfere with early evaluation of a therapeutic intervention delivered just after that measurement. The aim of the present study was to investigate the effects over time of a single static PV measurement on gas exchange and haemodynamics the PV measurements were taken using a super syringe and by using the constant flow method in patients with acute respiratory distress syndrome. Method We conducted a prospective randomized and controlled interventional study in an intensive care unit. The study was conducted in 17 patients with early acute respiratory distress syndrome ventilated with a tidal volume of 6.9 1.0 ml kg a plateau pressure of 27 7 cmH2O and a positive end-expiratory pressure PEEP of 10 cmH2O. They were all evaluated for 1 hour after each of the following two measurements was taken and during a control period in a randomized order generation of a PV curve .