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Báo cáo y học: " Gingival and plaque decontamination: Can we take a bite out of VAP"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Gingival and plaque decontamination: Can we take a bite out of VAP? | Available online at http ccforum.eom content 10 4 312 Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Gingival and plaque decontamination Can we take a bite out of VAP Jatinder Somal1 and Joseph M. Darby2 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 7th August 2006 This article is online at http ccforum.com content 10 4 312 2006 BioMed Central Ltd Critical Care 2006 10 312 DOI 101186 cc4999 Expanded Abstract Citation Fourrier F Dubois D Pronnier P Herbecq P Leroy O Desmettre T Pottier-Cau E Boutigny H Di Pompeo C Durocher A Roussel-Delvallez M Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit a double-blind placebo-controlled multicenter study. Crit Care Med 2005 33 1728-1735 1 . Background Poor oral hygiene and colonization of dental plaque is likely to play an important role in the development of ventilator-associated pneumonia VAP in many critically ill patients. Preliminary observations have suggested that dental plaque antiseptic decontamination PAD may reduce the frequency of VAP and ICU acquired bacteremia. Methods Design and setting Prospective multi-center doubleblind placebo-controlled trial in six French ICUs. Objective To document the effect of gingival and dental plaque antiseptic decontamination on the rate of nosocomial bacteremias and respiratory infections acquired in the ICU. Patients and intervention 228 non-edentulous patients requiring endotracheal intubation and mechanical ventilation with an anticipated ICU length of stay 5 days were randomized to receive 0.2 chlorhexidine gel or placebo applied to dental and gingival surfaces three times daily for the duration of their ICU stay until .