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Báo cáo y học: " No evidence for XMRV association in pediatric idiopathic diseases in France"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: No evidence for XMRV association in pediatric idiopathic diseases in France. | Jeziorski et al. Retrovirology 2010 7 63 http www.retrovirology.eom content 7 1 63 RETROVIROLOGY SHORT REPORT Open Access No evidence for XMRV association in pediatric idiopathic diseases in France 1.2 3 2 4 5 3 Eric Jeziorski 1 Vincent Foulongne Catherine Ludwig Djamel Louhaem Gilles Chiocchia Michel Segondy Michel Rodière2 Marc Sitbon1 Valerie Courgnaud1 Abstract Retroviruses have been linked to a variety of diseases such as neoplastic and immunodeficiency disorders and neurologic and respiratory diseases. Recently a novel infectious human retrovirus the xenotropic murine leukemia virus-related virus XMRV has been identified in cohorts of patients with either a familial type of prostate cancer or chronic fatigue syndrome. The apparent unrelatedness of these diseases raised the question of the potential involvement of XMRV in other diseases. Here we investigated the presence of XMRV in a selection of pediatric idiopathic infectious diseases with symptoms that are suggestive of a retroviral infection as well as in children with respiratory diseases and in adult patients with spondyloarthritis SpA . Using a XMRV env-nested PCR we screened 72 DNA samples obtained from 62 children hospitalized in the Montpellier university hospital France for hematological neurological or inflammatory pathologies 80 DNA samples from nasopharyngeal aspirates from children with respiratory diseases and 19 DNA samples from SpA. None of the samples tested was positive for XMRV or MLV-like env sequences indicating that XMRV is not involved in these pathologies. Findings Retroviruses have been isolated from a wide variety of animal species and have been linked to a broad range of diseases including neoplasia non-neoplastic hematological or inflammatory diseases immunodeficiencies and neurodegenerative and respiratory syndromes 1-3 . However in humans it was not until the early 1980 s that two pathogenic retroviruses were isolated a deltaretrovirus the human T cell leukemia virus HTLV and a

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