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Báo cáo khoa học: "Dexamethasone to prevent postextubation airway obstruction in adults: a prospective, randomized, double-blind, placebo-controlled study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: cc. | Available online http ccforum.eom content 11 4 R72 Research Dexamethasone to prevent postextubation airway obstruction in adults a prospective randomized double-blind placebo-Controlled study Chao-Hsien Lee1 Ming-Jen Peng1 and Chien-Liang Wu1 2 Open Access 1 Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Mackay Memorial Hospital No. 92 Section 2 Chung Shan North Road Taipei City 104 Taiwan 2Mackay Medicine Nursing and Management College No.92 Shengjing Rd. Beitou District Taipei City 112 Taiwan Corresponding author Chien-Liang Wu wuchienliang100@pchome.com.tw Received 31 Jan 2007 Revisions requested 14 Mar 2007 Revisions received 8 May 2007 Accepted 2 Jul 2007 Published 2 Jul 2007 Critical Care 2007 11 R72 doi 10.1186 cc5957 This article is online at http ccforum.com content 11 4 R72 2007 Lee et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Prophylactic steroid therapy to reduce the occurrence of postextubation laryngeal edema is controversial. Only a limited number of prospective trials involve adults in an intensive care unit. The purpose of this study was to ascertain whether administration of multiple doses of dexamethasone to critically ill intubated patients reduces or prevents the occurrence of postextubation airway obstruction. Another specific objective of our study was to investigate whether an after-effect that is a transient lingering benefit exists 24 hours after the discontinuation of dexamethasone. Methods A randomized placebo-controlled double-blind trial was conducted in an adult medical intensive care unit of a tertiary care hospital. Eighty-six patients who had been intubated for more than 48 hours with a cuff leak volume CLV of less than 110 ml