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Báo cáo y học: "Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142. | Retrovirology BioMed Central Open Access Short report Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACHI42 Kevin C Olivieri1 Robert M Scoggins1 Brooks Broderick1 Maria LC Powell1 Melissa A Alexander1 Marie-Louise Hammarskjold1 David Rekosh1 and David Camerini 2 Address Department of Microbiology and Myles H. Thaler Center for AIDS and Human Retrovirus Research University of Virginia Charlottesville VA 22908 USA and 2Department of Molecular Biology and Biochemistry Center for Immunology and Center for Virus Research University of California Irvine CA 92697-3900 USA Email Kevin C Olivieri - Kevin_Olivieri@dfci.harvard.edu Robert M Scoggins - robert.scoggins@Vanderbilt.Edu Brooks Broderick - bb5h@cms.mail.virginia.edu Maria LC Powell - mcpowell@fas.harvard.edu Melissa A Alexander - melissa.alexander@emory.edu Marie-Louise Hammarskjold - mh7g@virginia.edu David Rekosh - dr4u@virginia.edu David Camerini - David.Camerini@uci.edu Corresponding author Published 29 May 2008 Received 13 May 2008 Retrovirology 2008 5 42 doi 10.1186 1742-4690-5-42 Accepted 29 May 2008 This article is available from http www.retrovirology.cOm content 5 1 42 2008 Olivieri et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract AIDS-associated CCR5-tropic R5 HIV-1 clones isolated from a patient that never developed CXCR4-tropic HIV-1 replicate to a greater extent and cause greater cytopathic effects than R5 HIV-1 clones isolated before the onset of AIDS. Previously we showed that HIV-1 Env substantially contributed to the enhanced replication of an AIDS clone. In order to determine if Nef makes a similar contribution we cloned and phenotypically analyzed nef genes from a series of patient