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Báo cáo y học: "Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope. | Retrovirology BioMed Central Research Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope Daniel Lamb1 Alexander W Schuttelkopf2 Daan MF van Aalten2 and David W Brighty 1 Open Access Address 1The Biomedical Research Centre College of Medicine Ninewells Hospital The University Dundee DD1 9SY Scotland UK and 2The Division of Biological Chemistry and Drug Discovery College of Life Sciences University of Dundee Dow Street Dundee DD1 5EH Scotland UK Email Daniel Lamb - d.J.Lamb@dundee.ac.uk Alexander W Schuttelkopf - a.schuettelkopf@dundee.ac.uk Daan MF van Aalten - dava@davapc1.bioch.dundee.ac.uk David W Brighty - d.w.brighty@dundee.ac.uk Corresponding author Published 4 August 2008 Received 14 April 2008 Retrovirology 2008 5 70 doi 10.1186 1742-4690-5-70 Accepted 4 August 2008 This article is available from http www.retrovirology.cOm content 5 1 70 2008 Lamb et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human T-cell leukaemia virus HTLV-1 and bovine leukaemia virus BLV entry into cells is mediated by envelope glycoprotein catalyzed membrane fusion and is achieved by folding of the transmembrane glycoprotein TM from a rod-like pre-hairpin intermediate to a trimer-of-hairpins. For HTLV-1 and for several virus groups this process is sensitive to inhibition by peptides that mimic the C-terminal a-helical region of the trimer-of-hairpins. Results We now show that amino acids that are conserved between BLV and HTLV-1 TM tend to map to the hydrophobic groove of the central triple-stranded coiled coil and to the leash and C-terminal a-helical region LHR of the trimer-of-hairpins. Remarkably despite this .