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Báo cáo y học: " Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus. | Retrovirology BioMed Central Research Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus Melissa J Churchill 1 Lisa Chiavaroli1 Steven L Wesselingh1 2 3 and Paul R Gorry 1 2 3 Open Access Address rhe Macfarlane Burnet Institute for Medical Research and Public Health Melbourne Victoria Australia 2Department of Microbiology and Immunology University of Melbourne Melbourne Victoria Australia and 3Department of Medicine Monash University Melbourne Victoria Australia Email Melissa J Churchill - churchil@burnet.edu.au Lisa Chiavaroli - lisa@burnet.edu.au Steven L Wesselingh - stevew@burnet.edu.au Paul R Gorry - gorry@burnet.edu.au Corresponding authors Published I July 2007 Received 14 February 2007 Retrovirology 2007 4 43 doi 10.1186 1742-4690-4-43 Accepted 1 July 2007 This article is available from http www.retrovirology.cOm content 4 1 43 2007 Churchill et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The Sydney blood bank cohort SBBC of long-term survivors consists of multiple individuals infected with nef-deleted attenuated strains of human immunodeficiency virus type 1 HIV-1 . Although the cohort members have experienced differing clinical courses and now comprise slow progressors SP as well as long-term nonprogressors LTNP longitudinal analysis of nef long-terminal repeat LTR sequences demonstrated convergent nef LTR sequence evolution in SBBC SP and LTNP. Thus the in vivo pathogenicity of attenuated HIV-1 strains harboured by SBBC members is dictated by factors other than nef LTR. Therefore to determine whether defects in other .