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Báo cáo y học: "Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep. | Retrovirology BioMed Central Short report Open Access Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy observations in Bovine Leukemia Virus-infected sheep Makram Merimi1 Pavel Klener1 2 Maud Szynal1 Yvette Cleuter1 Claude Bagnis3 Pierre Kerkhofs4 Arsène Burny1 Philippe Martiat1 and Anne Van den Broeke 1 Address Laboratory of Experimental Hematology Institut Jules Bordet Université Libre de Bruxelles ULB 1000 Brussels Belgium 2Institute of Pathological Physiology Charles University Prague Czech Republic 3Etablissement Fran ais du Sang 13009 Marseille France and 4CERVA-CODA 1180 Uccle Belgium Email Makram Merimi - mmerimi@hotmail.com Pavel Klener - pklener@yahoo.com Maud Szynal - mszynal@ulb.ac.be Yvette Cleuter - yvette.cleuter@laposte.net Claude Bagnis - claude.bagnis@gmail.com Pierre Kerkhofs - piker@var.gov.be Arsène Burny- burny.a@fsagx.ac.be Philippe Martiat- pmartiat@ulb.ac.be Anne Van den Broeke - anne.vandenbroeke@bordet.be Corresponding author Published 23 July 2007 Received 7 March 2007 Retrovirology 2007 4 51 doi l0.ll86 l742-4690-4-51 Accepted 23 July 2007 This article is available from http www.retrovirology.cOm content 4 1 51 2007 Merimi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background During malignant progression tumor cells need to acquire novel characteristics that lead to uncontrolled growth and reduced immunogenicity. In the Bovine Leukemia Virus-induced ovine leukemia model silencing of viral gene expression has been proposed as a mechanism leading to immune evasion. However whether proviral expression in tumors is completely suppressed in vivo was not conclusively demonstrated. Therefore we studied viral expression