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Báo cáo y học: " microRNAs in viral oncogenesis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: microRNAs in viral oncogenesis. | Retrovirology BioMed Central Commentary microRNAs in viral oncogenesis Vinod Scaria and Vaibhav Jadhav Open Access Address GN Ramachandran Knowledge Center for Genome Informatics Institute of Genomics and Integrative Biology CSIR Mall Road Delhi 110 007 India Email Vinod Scaria - vinods@igib.res.in Vaibhav Jadhav - vaibhav.jadhav@igib.res.in Corresponding author Published 24 November 2007 Received 17 February 2007 Accepted 24 November 2007 Retrovirology 2007 4 82 doi l0.ll86 l 742-4690-4-82 This article is available from http www.retrovirology.cOm content 4 1 82 2007 Scaria and Jadhav licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract MicroRNAs are a recently discovered class of small noncoding functional RNAs. These molecules mediate post-transcriptional regulation of gene expression in a sequence specific manner. MicroRNAs are now known to be key players in a variety of biological processes and have been shown to be deregulated in a number of cancers. The discovery of viral encoded microRNAs especially from a family of oncogenic viruses has attracted immense attention towards the possibility of microRNAs as critical modulators of viral oncogenesis. The host-virus crosstalk mediated by microRNAs messenger RNAs and proteins is complex and involves the different cellular regulatory layers. In this commentary we describe models of microRNA mediated viral oncogenesis. Background Interest in the involvement of infectious agents in oncogenic transformation and more so viruses has been of historical importance probably starting with Rous discovery of filterable particles that could transmit avian sarcoma 1 . This was followed by the discovery .