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Báo cáo y học: "Role of the long cytoplasmic domain of the SIV Env glycoprotein in early and late stages of infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Role of the long cytoplasmic domain of the SIV Env glycoprotein in early and late stages of infection. | BioMed Central Retrovirology Research Open Access Role of the long cytoplasmic domain of the SIV Env glycoprotein in early and late stages of infection Andrei N Vzorov 1 Armin Weidmann1 4 Natalia L Kozyr2 Vladimir Khaoustov3 Boris Yoffe3 and Richard W Compans1 Address 1Dept. of Microbiology and Immunology and Emory Vaccine Center Emory University Atlanta GA USA 2Dept of Medicine and Emory Vaccine Center Emory University Atlanta GA USA 3Dept of Medicine Baylor College of Medicine Houston TX USA and 4MorphoSys AG Martinsried Planegg Germany Email Andrei N Vzorov - avzorov@emory.edu Armin Weidmann - Armin.Weidmann@morphosys.com Natalia L Kozyr - nkozyr@rmy.emory.edu Vladimir Khaoustov - adimirk@bcm.tmc.edu Boris Yoffe - byoffe@bcm.tmc.edu Richard W Compans - compans@microbio.emory.edu Corresponding author Published 14 December 2007 Received 20 September 2007 Accepted 14 December 2007 Retrovirology 2007 4 94 doi l0.l 186 1742-4690-4-94 This article is available from http www.retrovirology.cOm content 4 1 94 2007 Vzorov et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The Env glycoproteins of retroviruses play an important role in the initial steps of infection involving the binding to cell surface receptors and entry by membrane fusion. The Env glycoprotein also plays an important role in viral assembly at a late step of infection. Although the Env glycoprotein interacts with viral matrix proteins and cellular proteins associated with lipid rafts its possible role during the early replication events remains unclear. Truncation of the cytoplasmic tail CT of the Env glycoprotein is acquired by SIV in the course of adaptation to human cells and is known to be a determinant of SIV pathogenicity. Results We