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Báo cáo y học: "Functional diversity of HIV-1 envelope proteins expressed by contemporaneous plasma viruses"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Functional diversity of HIV-1 envelope proteins expressed by contemporaneous plasma viruses. | Retrovirology BioMed Central Research Functional diversity of HIV-I envelope proteins expressed by contemporaneous plasma viruses Tamara Nora Francine Bouchonnet Beatrice Labrosse Charlotte Charpentier Fabrizio Mammano Francois Clavel and Allan J Hance Open Access Address Unité de Recherche Antivirale INSERM U 552 Université Denis Diderot Paris 7 Paris F-75018 France Email Tamara Nora - nora@bichat.inserm.fr Francine Bouchonnet - fbouchon@bichat.inserm.fr Béatrice Labrosse - labrosse@bichat.inserm.fr Charlotte Charpentier - charlotte.charpentier@egp.ap-hop-paris.fr Fabrizio Mammano - mammano@pasteur.fr Francois Clavel - clavel@bichat.inserm.fr Allan J Hance - hance@bichat.inserm.fr Corresponding author Published 29 February 2008 Received 10 January 2008 Accepted 29 February 2008 Retrovirology 2008 5 23 doi l0.ll86 l742-4690-5-23 This article is available from http www.retrovirology.cOm content 5 1 23 2008 Nora et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Numerous studies have shown that viral quasi-species with genetically diverse envelope proteins Env replicate simultaneously in patients infected with the human immunodeficiency virus type 1 HIV-1 . Less information is available concerning the extent that envelope sequence diversity translates into a diversity of phenotypic properties including infectivity and resistance to entry inhibitors. Methods To study these questions we isolated genetically distinct contemporaneous clonal viral populations from the plasma of 5 HIV-1 infected individuals n 70 and evaluated the infectivity of recombinant viruses expressing Env proteins from the clonal viruses in several target cells. The sensitivity to entry inhibitors enfuvirtide TAK-799 soluble CD4 and .