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Báo cáo y học: "Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis. | Available online http ccforum.eom content 11 4 R79 Research Parenteral versus enteral nutrition effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis Michael J O Leary1 Aiqun Xue2 Christopher J Scarlett2 Andre Sevette2 Anthony J Kee2 and Ross C Smith2 Department of Intensive Care The St George Hospital Kogarah NSW 221 7 Australia department of Surgery Royal North Shore Hospital St Leonards NSW 2065 Australia Corresponding author Michael J O Leary m.oleary@unsw.edu.au Received 2 Nov 2006 Revisions requested 10 Feb 2007 Revisions received 30 May 2007 Accepted 16 Jul 2007 Published 16 Jul 2007 Critical Care 2007 11 R79 doi 10.1186 cc5972 This article is online at http ccforum.com content 11 4 R79 2007 O Leary et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Early nutrition is recommended for patients with sepsis but data are conflicting regarding the optimum route of delivery. Enteral nutrition EN compared with parenteral nutrition PN results in poorer achievement of nutritional goals but may be associated with fewer infections. Mechanisms underlying differential effects of the feeding route on patient outcomes are not understood but probably involve the immune system and the anabolic response to nutrients. We studied the effect of nutrition and the route of delivery of nutrition on cytokine profiles the growth hormone-insulin-like growth factor-1 IGF-I axis and a potential mechanism for immune and anabolic system interaction the suppressors of cytokine signaling SOCS in rodents with and without sepsis. Methods Male Sprague-Dawley rats were randomized to .