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Báo cáo y học: "Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction. | Available online http ccforum.eom content 11 5 R107 Research Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation experimental evidence for a novel mechanism of septic vascular dysfunction Marcela Helena Gambim1 Alipio de Oliveira do Carmo2 Luciana Marti2 Sidney Verissimo-Filho3 Lucia Rossetti Lopes3 and Mariano Janiszewski2 3 Division of Rheumatology University of São Paulo School of Medicine Avenida Doutor Arnaldo 455 01246-903 - São Paulo - SP 2Instituto de Ensino e Pesquisa Sociedade Beneficente Israelita-Brasileira Hospital Albert Einstein Avenida Albert Einstein 627 - Piso Chinuch 05651-901 - São Paulo - SP 3Pharmacology Department Biomedical Sciences Institute University of São Paulo Av. Prof. Lineu Prestes 1524. Cidade Universitária Armando de Salles Oliveira 05508-900 - São Paulo - SP Corresponding author Marcela Helena Gambim mgambim@gmail.com Received 30 May 2007 Revisions requested 23 Jul 2007 Revisions received 9 Aug 2007 Accepted 25 Sep 2007 Published 25 Sep 2007 Critical Care 2007 11 R107 doi 10.1186 cc6133 This article is online at http ccforum.com content 11 5 R1 07 2007 Gambim et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Several studies link hematological dysfunction to severity of sepsis. Previously we showed that platelet-derived microparticles from septic patients induce vascular cell apoptosis through the NADPH oxidase-dependent release of superoxide. We sought to further characterize the microparticledependent vascular injury pathway. Methods During septic shock there is increased generation of thrombin TNF-a and nitric oxide NO . Human platelets were exposed for 1 hour to the NO donor diethylamine-NONOate 0.5 pM .