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Báo cáo y học: "PAC in FACTT: Time to PAC it in"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: PAC in FACTT: Time to PAC it in? | Available online at http ccforum.eom content 12 1 301 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique PAC in FACTT Time to PAC it in Wissam Mansour 1 Eric B. Milbrandt 2 and Lillian L. Emlet2 1 Chief Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Assistant Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 6th February 2008 This article is online at http ccforum.com content 12 1 301 2008 BioMed Central Ltd Critical Care 2008 12 301 DOI 10.1186 cc6767 Expanded Abstract Citation Wheeler AP Bernard GR Thompson BT Schoenfeld D Wiedemann HP deBoisblanc B Connors AF Jr. Hite RD Harabin AL. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med 2006 354 2213-2224 1 . Background The balance between the benefits and the risks of pulmonary artery catheters PACs has not been established. Methods Objective To assess the safety and efficacy of PAC-guided vs. central venous catheter-guided management in reducing mortality and morbidity in patients with established acute lung injury ALI . Design Randomized controlled non-blinded trial. Setting 36 centers in the United States and 2 in Canada. Subjects 1000 patients with established acute lung injury of less than 48 hours duration. Subjects were excluded if they already had a PAC in place or had chronic conditions that could independently influence survival impair weaning or compromise compliance with the protocol such as dialysis dependence severe lung or neuromuscular disease or terminal illness. Intervention Subjects were randomized to hemodynamic management guided by a PAC or a CVC using an explicit management protocol. Outcomes Hospital mortality during the first 60 days before discharge .