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Báo cáo y học: " Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription. | Retrovirology BioMed Central Open Access Phosphorylation of HIV-I Tat by CDK2 in HIV-I transcription Tatyana Ammosova1 Reem Berro4 Marina Jerebtsova5 Angela Jackson2 Sharroya Charles3 Zachary Klase4 William Southerland2 Victor R Gordeuk1 Fatah Kashanchi4 and Sergei Nekhai 1 2 4 Address 1Center for Sickle Cell Disease Howard University College of Medicine 520 W Street N.W. Washington DC 20059 USA 2Department of Biochemistry and Molecular Biology Howard University College of Medicine 520 W Street N.W. Washington DC 20059 USA 3Program in Genetics Howard University College of Medicine 520 W Street N.W. Washington DC 20059 USA 4Department of Biochemistry and Molecular Biology The George Washington University Medical Center 2300 I Street N.W. Washington DC 20037 USA and 5Children s National Medical Center CRI Center III 111 Michigan Ave. N.W. Washington D.C. 20010-2970 USA Email Tatyana Ammosova - tammosova@mail.ru Reem Berro - ramroom@gmail.com Marina Jerebtsova - mjerebts@cnmc.org Angela Jackson - comptona99@hotmail.com Sharroya Charles - sho2roya@yahoo.com Zachary Klase - zklase@gwu.edu William Southerland - wsoutherland@howard.edu Victor R Gordeuk - vgoreduk@howard.edu Fatah Kashanchi - bcmfxk@gwumc.edu Sergei Nekhai - snekhai@howard.edu Corresponding author Published 03 November 2006 Received 27 July 2006 Accepted 03 November 2006 Retrovirology 2006 3 78 doi l0.ll86 l 742-4690-3-78 This article is available from http www.retrovirology.cOm content 3 1 78 2006 Ammosova et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Transcription of HIV-1 genes is activated by HIV-1 Tat protein which induces phosphorylation of RNA polymerase II RNAPII C-terminal domain CTD by CDK9 cyclin T1. Earlier we showed that .