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Báo cáo y học: " Molecular characterization of the HIV-1 gag nucleocapsid gene associated with vertical transmission"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:" Molecular characterization of the HIV-1 gag nucleocapsid gene associated with vertical transmission | BioMed Central Retrovirology Research Open Access Molecular characterization of the HIV-1 gag nucleocapsid gene associated with vertical transmission Brian P Wellensiek Vasudha Sundaravaradan Rajesh Ramakrishnan and Nafees Ahmad Address Department of Microbiology and Immunology College of Medicine The University of Arizona Health Sciences Center Tucson Arizona USA Email Brian P Wellensiek - bwellen1@u.arizona.edu Vasudha Sundaravaradan - vasudha@u.arizona.edu Rajesh Ramakrishnan - ramakris@bcm.tmc.edu Nafees Ahmad - nafees@u.arizona.edu Corresponding author Published 06 April 2006 Received 09 November 2005 Accepted 06 April 2006 Retrovirology2006 3 21 doi 10.1186 1742-4690-3-21 This article is available from http www.retrovirology.com content 3 1 21 2006Wellensiek et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The human immunodeficiency virus type I HIV-I nucleocapsid NC plays a pivotal role in the viral lifecycle including encapsulating the viral genome aiding in strand transfer during reverse transcription and packaging two copies of the viral genome into progeny virions. Another gag gene product p6 plays an integral role in successful viral budding from the plasma membrane and inclusion of the accessory protein Vpr within newly budding virions. In this study we have characterized the gag NC and p6 genes from six mother-infant pairs following vertical transmission by performing phylogenetic analysis and by analyzing the degree of genetic diversity evolutionary dynamics and conservation of functional domains. Results Phylogenetic analysis of 168 gag NC and p6 genes sequences revealed six separate subtrees that corresponded to each mother-infant pair suggesting that epidemiologically linked .