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Báo cáo y học: " HIV-1 associated dementia: symptoms and causes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 associated dementia: symptoms and causes | Retrovirology BioMed Central Review Open Access HIV-1 associated dementia symptoms and causes Mohammad Ghafouri1 Shohreh Amini2 Kamel Khalili1 and Bassel E Sawaya 1 Address Department of Neuroscience Center for Neurovirology Temple University School of Medicine Pennsylvania 19122 USA and 2Department of Biology College of Science and Technology Temple University Philadelphia Pennsylvania 19122 USA Email Mohammad Ghafouri - ghafouri@temple.edu Shohreh Amini - shohreh.amini@temple.edu Kamel Khalili - kamel.khalili@temple.edu Bassel E Sawaya - sawaya@temple.edu Corresponding author Published 19 May 2006 Received 18 March 2006 Retrovirology 2006 3 28 doi 10.1186 1742-4690-3-28 Accepted 19 May 2006 This article is available from http www.retrovirology.cOm content 3 1 28 2006 Ghafouri et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Despite the use of highly active antiretroviral therapy HAART neuronal cell death remains a problem that is frequently found in the brains of HIV-1-infected patients. HAART has successfully prevented many of the former end-stage complications of AIDS however with increased survival times the prevalence of minor HIV-1 associated cognitive impairment appears to be rising among AIDS patients. Further HIV-1 associated dementia HAD is still prevalent in treated patients as well as attenuated forms of HAD and CNS opportunistic disorders. HIV-associated cognitive impairment correlates with the increased presence in the CNS of activated though not necessarily HIV-1-infected microglia and CNS macrophages. This suggests that indirect mechanisms of neuronal injury and loss death occur in HIV AIDS as a basis for dementia since neurons are not themselves productively infected by HIV-1. In this review