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Báo cáo y học: "Insulin, intracerebral glucose and bedside biochemical monitoring utilizing microdialys"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Insulin, intracerebral glucose and bedside biochemical monitoring utilizing microdialysis. | Available online http ccforum.eom content 12 2 124 Commentary Insulin intracerebral glucose and bedside biochemical monitoring utilizing microdialysis Carl-Henrik Nordstrom Department of Neurosurgery Lund University Hospital SE 221 85 Lund Sweden Corresponding author Carl-Henrik Nordstrom carl-henrik.nordstrom@med.lu.se Published 31 March 2008 This article is online at http ccforum.com content 12 2 124 2008 BioMed Central Ltd Critical Care 2008 12 124 doi 10.1186 cc6826 See related research by Schlenk et al. http ccforum.com content 12 1 R9 Abstract Following subarachnoid hemorrhage hyperglycemia is strongly associated with complications and with impaired neurological recovery. Targeted insulin therapy for glycemic control might on the contrary have harmful effects by causing too low cerebral glucose levels. The study published by Schlenk and colleagues in the previous issue of Critical Care shows that insulin caused a significant decrease in the interstitial cerebral glucose concentration although the blood glucose level remained unaffected. Since several studies utilizing various analytical techniques have shown that cerebral blood flow and cerebral glucose uptake and metabolism are insulin-independent processes the observation remains unexplained. The study published by Schlenk and colleagues in the previous issue of Critical Care was initiated by clinical experience that after subarachnoid hemorrhage hyperglycemia is strongly associated with complications and impaired neurological recovery. Utilizing intracerebral microdialysis and bedside biochemical monitoring Schlenk and colleagues made the unexpected observation that insulin caused a significant decrease in the interstitial cerebral glucose concentration although the blood glucose level remained unaffected 1 . The technique of microdialysis was introduced more than 30 years ago for monitoring the animal brain and has become a standard technique in neuroscience with well over 11 000 publications 2 3 . .