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Báo cáo y học: "The health related quality of life of people living with HIV/AIDS in sub-Saharan Africa - a literature review and focus group study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The health related quality of life of people living with HIV/AIDS in sub-Saharan Africa - a literature review and focus group study. | Robberstad and Olsen Cost Effectiveness and Resource Allocation 2010 8 5 http www.resource-allocation.eom content 8 1 5 COST EFFECTIVENESS AND RESOURCE ALLOCATION RESEARCH Open Access The health related quality of life of people living with HIV AIDS in sub-Saharan Africa - a literature review and focus group study Bjarne Robberstad 1 and Jan Abel Olsen2 Abstract Background While health outcomes of HIV AIDS treatments in terms of increased longevity has been the subject of much research there appears to be very limited research on the improved health related quality of life HRQL that can be applied in cost-utility analyses in Africa south of the Sahara SSA . Most of the literature that does exist present HRQL measured by disease specific instruments but such data is of little use as input to economic evaluations. Methods A systematic review of the literature on HRQL weights for people living with HIV AIDS in Africa was performed and the findings are presented and interpreted. We also use focus group discussions in panels of clinical AIDS experts to test the preference based on a generic descriptive system EQ-5D. We contrast quality of life with and without antiretroviral treatment ART and with and without treatment failure. Results In only four papers were the HRQL weights for HIV AIDS in sub-Saharan Africa estimated with generic preference based methodologies that can be directly applied in economic evaluation. A total of eight studies were based on generic health profiles. While such health profiles are not preference based the scores could potentially be transformed into health state utilities. Most of the available literature 20 papers utilized disease specific instrument which are not applicable for economic evaluation. The focus group discussions revealed that HRQL weights are strongly correlated to disease stage. Furthermore clinical experts consistently report that ART has a strong positive impact on the HRQL of patients although this effect appears to .