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Báo cáo y học: "Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats. | Available online http ccforum.eom content 1 2 4 R86 Research Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats Toshiaki Iba1 and Taku Miyasho2 Department of Emergency and Disaster Medicine Juntendo University Tokyo Japan 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421 Japan department of Veterinary Biochemistry School of Veterinary Medicine Rakuno Gakuen University 582 Bunkyodai-Midorimachi Ebetsu Hokkaido 069-8501 Japan Corresponding author Toshiaki Iba toshiiba@cf6.so-net.ne.jp Received 28 Apr 2008 Revisions requested 4 Jun 2008 Revisions received 25 Jun 2008 Accepted 6 Jul 2008 Published 6 Jul 2008 Critical Care 2008 12 R86 doi 10.1186 cc6943 This article is online at http ccforum.com content 12 4 R86 2008 Iba and Miyasho licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Anticoagulant therapy attracts much attention for the treatment of severe sepsis since recent studies have revealed that some anticoagulants have the ability to regulate the inflammatory response. The purpose of this study was to examine whether danaparoid sodium DA is effective for the treatment of organ dysfunction in sepsis. Methods Sixty-four Wistar rats were intravenously injected with 5.0 mg kg of lipopolysaccharide LPS and then divided into two groups the DA group and the control group n 32 each . The DA group was injected intravenously with 400 U kg of DA immediately after LPS injection whereas the control group received saline. Blood samples were drawn at 1 6 12 and 24 hours after LPS injection and organ damage markers and coagulation markers were measured. In the other series 10 rats treated with LPS were divided into DA and control groups n 5 each . Blood .