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Báo cáo y học: "Dialysis dose in acute kidney injury: no time for therapeutic nihilism – a critical appraisal of the Acute Renal Failure Trial Network study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Dialysis dose in acute kidney injury: no time for therapeutic nihilism – a critical appraisal of the Acute Renal Failure Trial Network study. | Available online http ccforum.eom content 12 5 308 Viewpoint Dialysis dose in acute kidney injury no time for therapeutic nihilism - a critical appraisal of the Acute Renal Failure Trial Network study Claudio Ronco1 2 Dinna Cruz1 2 Helen Oudemans van Straaten3 Patrick Honore4 Andrew House5 Du Bin6 and Noel Gibney7 1 Nephrology Department St Bortolo Hospital Viale Rodolfi 37 36100 Vicenza Italy international Renal Research Institute Vicenza IRRIV Viale Rodolfi 37 36100 Vicenza Italy 3Department of Intensive Care Onze Lieve Vrouwe Gasthuis Oosterpark 9 1091 AC Amsterdam the Netherlands 4Intensive Care Unit St-Pierre Para-Universitary Hospital 9 Avenue Reine Fabiola 1340 Ottignies-Louvain-la-Neuve Belgium 5London Health Sciences Centre 339 Windermere Road London Ontario Canada N6A 5A5 6Medical Intensive Care Unit Peking Union Medical College Hospital Shuaifuyuan 1 Wangfujing Beijing 100730 China 7Division of Critical Care Medicine University of Alberta 3C1.12 Walter C. Mackenzie Centre 8440-112 Street Edmonton Alberta T6G 2B7 Canada Corresponding author Claudio Ronco Cronco@goldnet.it Published 16 October 2008 This article is online at http ccforum.com content 12 5 308 2008 BioMed Central Ltd Critical Care 2008 12 308 doi 10.1186 cc7016 Abstract The optimal dialysis dose for acute kidney injury is a matter of great controversy. Clinical trials predominantly single-center studies have shown conflicting results. The Acute Renal Failure Trial Network ATN Study was designed to compare clinical outcomes between patients allocated to an intensive dose versus a less-intensive dose of renal replacement therapy. Recently the results of this large randomized controlled multicenter study were published. The present article will discuss certain aspects of this trial the overall design the baseline patient characteristics and comparison of the results with earlier studies. Finally the article will address the implications of the ATN Study results for clinical practice. .