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Báo cáo y học: "Cardiorespiratory effects of spontaneous breathing in two different models of experimental lung injury: a randomized controlled trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cardiorespiratory effects of spontaneous breathing in two different models of experimental lung injury: a randomized controlled trial. | Available online http ccforum.eom content 1 2 6 R135 Research Cardiorespiratory effects of spontaneous breathing in two different models of experimental lung injury a randomized controlled trial Dirk Varelmann1 Thomas Muders1 Jorg Zinserling1 Ulf Guenther1 Anders Magnusson2 Goran Hedenstierna3 Christian Putensen1 and Hermann Wrigge1 department of Anesthesiology and Intensive Care Medicine University of Bonn Sigmund-Freud-Strasse 25 D-53105 Bonn Germany department of Radiology University of Uppsala University Hospital SE-75185 Uppsala Sweden department of Clinical Physiology University of Uppsala University Hospital SE-75185 Uppsala Sweden Corresponding author Hermann Wrigge hermann.wrigge@ukb.uni-bonn.de Received 22 Jul 2008 Revisions requested 29 Aug 2008 Revisions received 3 Oct 2008 Accepted 4 Nov 2008 Published 4 Nov 2008 Critical Care 2008 12 R135 doi 10.1186 cc7108 This article is online at http ccforum.com content 12 6 R135 2008 Varelmann et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Acute lung injury ALI can result from various insults to the pulmonary tissue. Experimental and clinical data suggest that spontaneous breathing SB during pressure-controlled ventilation PCV in ALI results in better lung aeration and improved oxygenation. Our objective was to evaluate whether the addition of SB has different effects in two different models of ALI. Methods Forty-four pigs were randomly assigned to ALI resulting either from hydrochloric acid aspiration HCl-ALI or from increased intra-abdominal pressure plus intravenous oleic acid injections OA-ALI and were ventilated in PCV mode either with SB PCV SB or without SB PCV - SB . Cardiorespiratory variables were measured at baseline .