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Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells | Retrovirology BioMed Central Research Open Access The role of cyclin D2 and p2l wafl in human T-cell leukemia virus type 1 infected cells Kylene Kehn1 Longwen Deng1 Cynthia de la Fuente1 Katharine Strouss1 Kaili Wu1 Anil Maddukuri1 Shanese Baylor1 Robyn Rufner2 Anne Pumfery1 Maria Elena Bottazzi3 and Fatah Kashanchi 1 4 Address Department of Biochemistry and Molecular Biology The George Washington University Medical Center Washington DC 20037 USA 2Center for Microscopy and Image Analysis The George Washington University Medical Center Washington DC 20037 USA 3Department of Microbiology and Tropical Medicine The George Washington University Medical Center Washington DC 20037 USA and 4The Institute for Genomics Research Rockville MD 20850 USA Email Kylene Kehn - bcmkwk@gwumc.edu Longwen Deng - bcmfxk@gwumc.edu Cynthia de la Fuente - bcmclf@gwumc.edu Katharine Strouss - strouss@gwu.edu Kaili Wu - bcmfxk@gwumc.edu Anil Maddukuri - bcmfxk@gwumc.edu Shanese Baylor - bcmfkx@gwumc.edu Robyn Rufner - anarrr@gwumc.edu Anne Pumfery - bcmamp@gwumc.edu Maria Elena Bottazzi - mtmmeb@gwumc.edu Fatah Kashanchi - bcmfxk@gwumc.edu Corresponding author Published 13 April 2004 Received 15 March 2004 Accepted 13 April 2004 Retrovirology 2004 1 6 This article is available from http www.retrovirology.cOm content 1 1 6 2004 Kehn et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background The human T-cell leukemia virus type 1 HTLV-1 Tax protein indirectly influences transcriptional activation signal transduction cell cycle control and apoptosis. The function of Tax primarily relies on protein-protein interactions. We have previously shown that Tax upregulates the cell cycle checkpoint proteins p21 waf1 and cyclin D2. Here we describe the consequences of upregulating these G1 S checkpoint regulators