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Báo cáo y học: "HIV-1 encoded candidate micro-RNAs and their cellular targets"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 encoded candidate micro-RNAs and their cellular targets | Retrovirology BioMed Central Short report Open Access HIV-I encoded candidate micro-RNAs and their cellular targets Yamina Bennasser1 Shu-Yun Le2 Man Lung Yeung1 and Kuan-Teh Jeang 1 Address 1Molecular Virology Section Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland 20892-0460 USA and 2Laboratory of Experimental and Computational Biology National Cancer Institute Center for Cancer Research National Cancer Institute Frederick MD 21702 USA Email Yamina Bennasser - YBennasser@niaid.nih.gov Shu-Yun Le - shuyun@ncifcrf.gov Man Lung Yeung - yeungm@niaid.nih.gov Kuan-Teh Jeang - KJEANG@niaid.nih.gov Corresponding author Published 15 December 2004 Received 17 November 2004 Accepted 15 December 2004 Retrovirology 2004 1 43 doi l0.ll86 l742-4690-l-43 This article is available from http www.retrovirology.cOm content l l 43 2004 Bennasser et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract MicroRNAs miRNAs are small RNAs of 2l-25 nucleotides that specifically regulate cellular gene expression at the post-transcriptional level. miRNAs are derived from the maturation by cellular RNases III of imperfect stem loop structures of 70 nucleotides. Evidence for hundreds of miRNAs and their corresponding targets has been reported in the literature for plants insects invertebrate animals and mammals. While not all of these miRNA target pairs have been functionally verified some clearly serve roles in regulating normal development and physiology. Recently it has been queried whether the genome of human viruses like their cellular counterpart also encode miRNA. To date there has been only one report pertaining to this question. The Epstein-Barr .