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Báo cáo y học: " Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5 | Retrovirology BioMed Central Research Open Access Modulating HIV-I replication by RNA interference directed against human transcription elongation factor SPT5 Yueh-Hsin Ping1 3 Chia-ying Chu1 Hong Cao1 Jean-Marc Jacque2 Mario Stevenson2 and Tariq M Rana 1 Address Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School 364 Plantation Street Worcester MA 01605 USA 2Program in Molecular Medicine University of Massachusetts Medical School 373 Plantation Street Worcester MA 01605 USA and 3Department and Institute of Pharmacology National Yang-Ming University Shih-Pai Taipei 11221 Taiwan Email Yueh-Hsin Ping - yhping@ym.edu.tw Chia-ying Chu - chia-ying.chu@umassmed.edu Hong Cao - hong.cao@umassmed.edu JeanMarc Jacque - jean-marc.jacque@umassmed.edu Mario Stevenson - mariostevenson@umassmed.edu Tariq M Rana - tariq.rana@umassmed.edu Corresponding author Published 27 December 2004 Received 17 December 2004 Accepted 27 December 2004 Retrovirology 2004 1 46 doi l0.ll86 l742-4690-l-46 This article is available from http www.retrovirology.cOm content l l 46 2004 Ping et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Several cellular positive and negative elongation factors are involved in regulating RNA polymerase II processivity during transcription elongation in human cells. In recruiting several of these regulatory factors to the 5 long terminal repeat LTR promoter during transcription elongation HIV-l modulates replication of its genome in a process mediated by the virus-encoded transactivator Tat. One particular cellular regulatory factor DSIF subunit human SPT5 hSpt5 has been implicated in both positively and negatively regulating transcriptional elongation but its